The synthesis of naturally occurring peptides and their analogs

T. Cupido; J. Tulla-Puche; J. Spengler; F. Albericio

The synthesis of naturally occurring peptides and their analogs

T. Cupido
, J. Tulla-Puche
, J. Spengler
, F. Albericio

University of Barcelona

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

290 Citas (Scopus)

Resumen

The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

Idioma original	Inglés
Páginas (desde-hasta)	768-783
Número de páginas	16
Publicación	Current Opinion in Drug Discovery and Development
Volumen	10
N.º	6
Estado	Publicada - nov. 2007
Publicado de forma externa	Sí

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title = "The synthesis of naturally occurring peptides and their analogs",

abstract = "The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.",

keywords = "Acyl migration, Biosynthesis, Chemical ligation, Cyclic peptides, NRP, Pharmaceutical peptide, Pseudoproline, Resin, Solid phase, Total synthesis, Unnatural amino acids",

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AU - Cupido, T.

AU - Tulla-Puche, J.

AU - Spengler, J.

AU - Albericio, F.

PY - 2007/11

Y1 - 2007/11

N2 - The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

AB - The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

KW - Acyl migration

KW - Biosynthesis

KW - Chemical ligation

KW - Cyclic peptides

KW - NRP

KW - Pharmaceutical peptide

KW - Pseudoproline

KW - Resin

KW - Solid phase

KW - Total synthesis

KW - Unnatural amino acids

UR - https://www.scopus.com/pages/publications/35948950255

M3 - Artículo de revisión

C2 - 17987528

AN - SCOPUS:35948950255

SN - 1367-6733

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JO - Current Opinion in Drug Discovery and Development

JF - Current Opinion in Drug Discovery and Development

IS - 6

ER -

The synthesis of naturally occurring peptides and their analogs

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