TY - JOUR
T1 - Siamese depsipeptides
T2 - Constrained bicyclic architectures
AU - Ruiz-Rodriguez, Javier
AU - Spengler, Jan
AU - Albericio, Fernando
PY - 2009/10/26
Y1 - 2009/10/26
N2 - The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a natural bioactive depsipeptide (sansalvamide A) gives analogues with greater activity, and thereby provides additional information on structure-activity relationships (see structures).
AB - The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a natural bioactive depsipeptide (sansalvamide A) gives analogues with greater activity, and thereby provides additional information on structure-activity relationships (see structures).
KW - Biological activity
KW - Bioorganic chemistry
KW - Depsipeptides
KW - Structure-activity relationships
KW - Tartaric acid
UR - http://www.scopus.com/inward/record.url?scp=70350302210&partnerID=8YFLogxK
U2 - 10.1002/anie.200904135
DO - 10.1002/anie.200904135
M3 - Artículo
C2 - 19810072
AN - SCOPUS:70350302210
SN - 1433-7851
VL - 48
SP - 8564
EP - 8567
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 45
ER -