Orthogonally protected, carboxy-activated L-homoisoserine, 2-methyl-L-homoisoserine, and homoisocysteine derivatives. New building blocks for peptide and depsipeptide modification

Klaus Burger, Gabor Radics, Lothar Hennig, Christoph Böttcher, Jan Spengler, Fernando Albericio

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

4 Citas (Scopus)

Resumen

Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-homoisoserine and rac. homoisocysteine have been developed. The new orthogonally protected and carboxy-activated building blocks are GABA as well as α-hydroxy and α-mercapto acid derivatives, suitable for the construction of peptide and depsipeptide surrogates.

Idioma originalInglés
Páginas (desde-hasta)763-776
Número de páginas14
PublicaciónMonatshefte fur Chemie
Volumen136
N.º5
DOI
EstadoPublicada - may. 2005
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Orthogonally protected, carboxy-activated L-homoisoserine, 2-methyl-L-homoisoserine, and homoisocysteine derivatives. New building blocks for peptide and depsipeptide modification'. En conjunto forman una huella única.

Citar esto