TY - JOUR
T1 - Hexafluoroacetone as protecting and activating reagent
T2 - Reactions of hexafluoroacetone with α-keto acids
AU - Spengler, Jan
AU - Osipov, Sergej N.
AU - Heistracher, Elisabeth
AU - Haas, Alois
AU - Burger, Klaus
PY - 2004/6
Y1 - 2004/6
N2 - Hexafluoroacetone and α-keto acids react to give 5,5-bis(trifluoromethyl) substituted 2(5H)-furanones and/or 2,2-bis(trifluoromethyl)-1,3-dioxolan-4-ones depending upon the substituent pattern of the side chain of the acid. A fluoroanalogue of the natural product zymonic acid was obtained from ethyl 3,3,3-trifluoropyruvate and 2-oxosuccinic acid in one step.
AB - Hexafluoroacetone and α-keto acids react to give 5,5-bis(trifluoromethyl) substituted 2(5H)-furanones and/or 2,2-bis(trifluoromethyl)-1,3-dioxolan-4-ones depending upon the substituent pattern of the side chain of the acid. A fluoroanalogue of the natural product zymonic acid was obtained from ethyl 3,3,3-trifluoropyruvate and 2-oxosuccinic acid in one step.
KW - α-Keto acids
KW - 2,2-Bis(trifluoromethyl)-1,3-dioxolan-4-ones
KW - 5,5-Bis(trifluoromethyl)-2(5H)-furanones
KW - 5-Trifluoromethyl-2(5H)-furanones
KW - Butenolides
KW - Hexafluoroacetone
KW - Zymonic acid
UR - https://www.scopus.com/pages/publications/3242777037
U2 - 10.1016/j.jfluchem.2004.01.021
DO - 10.1016/j.jfluchem.2004.01.021
M3 - Artículo
AN - SCOPUS:3242777037
SN - 0022-1139
VL - 125
SP - 1019
EP - 1023
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 6
ER -