Hexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides

Christoph Böttcher; Jan Spengler; Samy A. Essawy; Klaus Burger

Hexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides

Christoph Böttcher, Jan Spengler, Samy A. Essawy, Klaus Burger

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

18 Citas (Scopus)

Resumen

N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ω-activated Asp, Glu, and Aad derivatives and glycosylamines. The synthetic value of the new building blocks was demonstrated by the concise incorporation of N-glycosylated Asn, Gln, and Aad ω-amides into glycopeptides.

Idioma original	Inglés
Páginas (desde-hasta)	853-863
Número de páginas	11
Publicación	Monatshefte fur Chemie
Volumen	135
N.º	7
Estado	Publicada - jul. 2004
Publicado de forma externa	Sí

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abstract = "N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ω-activated Asp, Glu, and Aad derivatives and glycosylamines. The synthetic value of the new building blocks was demonstrated by the concise incorporation of N-glycosylated Asn, Gln, and Aad ω-amides into glycopeptides.",

keywords = "Dielectrophiles, Hexafluoroacetone, N-Glycopeptides, N-Glycosylamino acids, N-Glycosylation",

author = "Christoph B{\"o}ttcher and Jan Spengler and Essawy, {Samy A.} and Klaus Burger",

year = "2004",

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T1 - Hexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides

AU - Böttcher, Christoph

AU - Spengler, Jan

AU - Essawy, Samy A.

AU - Burger, Klaus

PY - 2004/7

Y1 - 2004/7

N2 - N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ω-activated Asp, Glu, and Aad derivatives and glycosylamines. The synthetic value of the new building blocks was demonstrated by the concise incorporation of N-glycosylated Asn, Gln, and Aad ω-amides into glycopeptides.

AB - N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ω-activated Asp, Glu, and Aad derivatives and glycosylamines. The synthetic value of the new building blocks was demonstrated by the concise incorporation of N-glycosylated Asn, Gln, and Aad ω-amides into glycopeptides.

KW - Dielectrophiles

KW - Hexafluoroacetone

KW - N-Glycopeptides

KW - N-Glycosylamino acids

KW - N-Glycosylation

UR - http://www.scopus.com/inward/record.url?scp=3242672612&partnerID=8YFLogxK

M3 - Artículo

AN - SCOPUS:3242672612

SN - 0026-9247

VL - 135

SP - 853

EP - 863

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

IS - 7

ER -

Hexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides

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