Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste; Jonathan Liria; Naomi L. Forrester; Dileyvic Giambalvo; Maria Moncada; Kanya C. Long; Dulce Morón; Nuris de Manzione; Robert B. Tesh; Eric S. Halsey; Tadeusz J. Kochel; Rosa Hernandez; Juan Carlos Navarro; Scott C. Weaver

doi:10.3201/eid2110.141660

Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste, Jonathan Liria, Naomi L. Forrester, Dileyvic Giambalvo, Maria Moncada, Kanya C. Long, Dulce Morón, Nuris de Manzione, Robert B. Tesh, Eric S. Halsey, Tadeusz J. Kochel, Rosa Hernandez, Juan Carlos Navarro, Scott C. Weaver

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Resumen

In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

Idioma original	Inglés
Páginas (desde-hasta)	1742-1750
Número de páginas	9
Publicación	Emerging Infectious Diseases
Volumen	21
N.º	10
DOI	https://doi.org/10.3201/eid2110.141660
Estado	Publicada - 1 sep. 2015
Publicado de forma externa	Sí

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© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.

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Auguste, A. J., Liria, J., Forrester, N. L., Giambalvo, D., Moncada, M., Long, K. C., Morón, D., de Manzione, N., Tesh, R. B., Halsey, E. S., Kochel, T. J., Hernandez, R., Navarro, J. C., & Weaver, S. C. (2015). Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010. Emerging Infectious Diseases, 21(10), 1742-1750. https://doi.org/10.3201/eid2110.141660

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title = "Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010",

abstract = "In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estaci{\'o}n village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.",

author = "Auguste, {Albert J.} and Jonathan Liria and Forrester, {Naomi L.} and Dileyvic Giambalvo and Maria Moncada and Long, {Kanya C.} and Dulce Mor{\'o}n and {de Manzione}, Nuris and Tesh, {Robert B.} and Halsey, {Eric S.} and Kochel, {Tadeusz J.} and Rosa Hernandez and Navarro, {Juan Carlos} and Weaver, {Scott C.}",

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Auguste, AJ, Liria, J, Forrester, NL, Giambalvo, D, Moncada, M, Long, KC, Morón, D, de Manzione, N, Tesh, RB, Halsey, ES, Kochel, TJ, Hernandez, R, Navarro, JC & Weaver, SC 2015, 'Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010', Emerging Infectious Diseases, vol. 21, n.º 10, pp. 1742-1750. https://doi.org/10.3201/eid2110.141660

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T1 - Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

AU - Auguste, Albert J.

AU - Liria, Jonathan

AU - Forrester, Naomi L.

AU - Giambalvo, Dileyvic

AU - Moncada, Maria

AU - Long, Kanya C.

AU - Morón, Dulce

AU - de Manzione, Nuris

AU - Tesh, Robert B.

AU - Halsey, Eric S.

AU - Kochel, Tadeusz J.

AU - Hernandez, Rosa

AU - Navarro, Juan Carlos

AU - Weaver, Scott C.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

AB - In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

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Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

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