Asymmetric synthesis of α-unsubstituted β-hydroxy acids

Jan Spengler; Fernando Albericio

doi:10.2174/157017908784221558

Asymmetric synthesis of α-unsubstituted β-hydroxy acids

Jan Spengler, Fernando Albericio

University of Barcelona

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

8 Citas (Scopus)

Resumen

α-Unsubstituted β-hydroxy acid (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.

Idioma original	Inglés
Páginas (desde-hasta)	151-161
Número de páginas	11
Publicación	Current Organic Synthesis
Volumen	5
N.º	2
DOI	https://doi.org/10.2174/157017908784221558
Estado	Publicada - may. 2008
Publicado de forma externa	Sí

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title = "Asymmetric synthesis of α-unsubstituted β-hydroxy acids",

abstract = "α-Unsubstituted β-hydroxy acid (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.",

keywords = "β-lactones, 3-hydroxycarboxylic acids, Arndt-Eister homologation, Asymmetric aldol reactions, Asymmetric reduction, Cyclic sulfates, Cyclic sulfites, Reductive cleavage, Reformatsky reactions",

author = "Jan Spengler and Fernando Albericio",

year = "2008",

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AU - Albericio, Fernando

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AB - α-Unsubstituted β-hydroxy acid (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.

KW - β-lactones

KW - 3-hydroxycarboxylic acids

KW - Arndt-Eister homologation

KW - Asymmetric aldol reactions

KW - Asymmetric reduction

KW - Cyclic sulfates

KW - Cyclic sulfites

KW - Reductive cleavage

KW - Reformatsky reactions

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DO - 10.2174/157017908784221558

M3 - Artículo de revisión

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SN - 1570-1794

VL - 5

SP - 151

EP - 161

JO - Current Organic Synthesis

JF - Current Organic Synthesis

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ER -

Asymmetric synthesis of α-unsubstituted β-hydroxy acids

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