An efficient synthesis of N-methylamino acids and some of their derivatives

Jan Spengler; Klaus Burger

doi:10.1055/s-1998-1998

An efficient synthesis of N-methylamino acids and some of their derivatives

Jan Spengler, Klaus Burger

Leipzig University

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

30 Citas (Scopus)

Resumen

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

Idioma original	Inglés
Páginas (desde-hasta)	67-70
Número de páginas	4
Publicación	Synthesis
N.º	1
DOI	https://doi.org/10.1055/s-1998-1998
Estado	Publicada - ene. 1998
Publicado de forma externa	Sí

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title = "An efficient synthesis of N-methylamino acids and some of their derivatives",

abstract = "N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.",

keywords = "Hexafluoroacetone, N-chloromethylation, N-methylamino acids and derivatives, Triethylsilane",

author = "Jan Spengler and Klaus Burger",

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doi = "10.1055/s-1998-1998",

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AU - Burger, Klaus

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AB - N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

KW - Hexafluoroacetone

KW - N-chloromethylation

KW - N-methylamino acids and derivatives

KW - Triethylsilane

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U2 - 10.1055/s-1998-1998

DO - 10.1055/s-1998-1998

M3 - Artículo

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An efficient synthesis of N-methylamino acids and some of their derivatives

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