The synthesis of naturally occurring peptides and their analogs

T. Cupido; J. Tulla-Puche; J. Spengler; F. Albericio

The synthesis of naturally occurring peptides and their analogs

T. Cupido
, J. Tulla-Puche
, J. Spengler
, F. Albericio

University of Barcelona

Research output: Contribution to journal › Review article › peer-review

289 Scopus citations

Abstract

The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

Original language	English
Pages (from-to)	768-783
Number of pages	16
Journal	Current Opinion in Drug Discovery and Development
Volume	10
Issue number	6
State	Published - Nov 2007
Externally published	Yes

Keywords

Acyl migration
Biosynthesis
Chemical ligation
Cyclic peptides
NRP
Pharmaceutical peptide
Pseudoproline
Resin
Solid phase
Total synthesis
Unnatural amino acids

Cite this

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title = "The synthesis of naturally occurring peptides and their analogs",

abstract = "The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.",

keywords = "Acyl migration, Biosynthesis, Chemical ligation, Cyclic peptides, NRP, Pharmaceutical peptide, Pseudoproline, Resin, Solid phase, Total synthesis, Unnatural amino acids",

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AU - Cupido, T.

AU - Tulla-Puche, J.

AU - Spengler, J.

AU - Albericio, F.

PY - 2007/11

Y1 - 2007/11

N2 - The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

AB - The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

KW - Acyl migration

KW - Biosynthesis

KW - Chemical ligation

KW - Cyclic peptides

KW - NRP

KW - Pharmaceutical peptide

KW - Pseudoproline

KW - Resin

KW - Solid phase

KW - Total synthesis

KW - Unnatural amino acids

UR - https://www.scopus.com/pages/publications/35948950255

M3 - Artículo de revisión

C2 - 17987528

AN - SCOPUS:35948950255

SN - 1367-6733

VL - 10

SP - 768

EP - 783

JO - Current Opinion in Drug Discovery and Development

JF - Current Opinion in Drug Discovery and Development

IS - 6

ER -

The synthesis of naturally occurring peptides and their analogs

Abstract

Keywords

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