Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

Jan Spengler; Beate Koksch; Fernando Albericio

doi:10.1002/bip.20858

Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

Jan Spengler
, Beate Koksch
, Fernando Albericio

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.

Original language	English
Pages (from-to)	823-828
Number of pages	6
Journal	Biopolymers - Peptide Science Section
Volume	88
Issue number	6
DOIs	https://doi.org/10.1002/bip.20858
State	Published - 2007
Externally published	Yes

Keywords

Automated solid-phase depsipeptide synthesis
Ester peptides
Helical coiled coil peptides

Access to Document

10.1002/bip.20858

Cite this

@article{06a8418896ed4b21afe54f1086e6f18e,

title = "Simple machine-assisted protocol for solid-phase synthesis of depsipeptides",

abstract = "A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.",

keywords = "Automated solid-phase depsipeptide synthesis, Ester peptides, Helical coiled coil peptides",

author = "Jan Spengler and Beate Koksch and Fernando Albericio",

year = "2007",

doi = "10.1002/bip.20858",

language = "Ingl{\'e}s",

volume = "88",

pages = "823--828",

journal = "Biopolymers - Peptide Science Section",

issn = "0006-3525",

publisher = "John Wiley and Sons Inc",

number = "6",

}

TY - JOUR

T1 - Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

AU - Spengler, Jan

AU - Koksch, Beate

AU - Albericio, Fernando

PY - 2007

Y1 - 2007

N2 - A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.

AB - A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.

KW - Automated solid-phase depsipeptide synthesis

KW - Ester peptides

KW - Helical coiled coil peptides

UR - https://www.scopus.com/pages/publications/37549013765

U2 - 10.1002/bip.20858

DO - 10.1002/bip.20858

M3 - Artículo

C2 - 17922494

AN - SCOPUS:37549013765

SN - 0006-3525

VL - 88

SP - 823

EP - 828

JO - Biopolymers - Peptide Science Section

JF - Biopolymers - Peptide Science Section

IS - 6

ER -

Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this