Siamese depsipeptides: Constrained bicyclic architectures

Javier Ruiz-Rodriguez; Jan Spengler; Fernando Albericio

doi:10.1002/anie.200904135

Siamese depsipeptides: Constrained bicyclic architectures

Javier Ruiz-Rodriguez
, Jan Spengler
, Fernando Albericio

Institute for Research in Biomedicine
Biomaterials and Nanomedicine
University of Barcelona

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a natural bioactive depsipeptide (sansalvamide A) gives analogues with greater activity, and thereby provides additional information on structure-activity relationships (see structures).

Original language	English
Pages (from-to)	8564-8567
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	45
DOIs	https://doi.org/10.1002/anie.200904135
State	Published - 26 Oct 2009
Externally published	Yes

Keywords

Biological activity
Bioorganic chemistry
Depsipeptides
Structure-activity relationships
Tartaric acid

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10.1002/anie.200904135

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KW - Biological activity

KW - Bioorganic chemistry

KW - Depsipeptides

KW - Structure-activity relationships

KW - Tartaric acid

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AN - SCOPUS:70350302210

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JO - Angewandte Chemie - International Edition

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ER -

Siamese depsipeptides: Constrained bicyclic architectures

Abstract

Keywords

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