N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: Application to Sansalvamide A peptide analogs

Ana I. Fernández-Llamazares; Jesús García; Vanessa Soto-Cerrato; Ricardo Pérez-Tomás; Jan Spengler; Fernando Albericio

doi:10.1039/c3cc41788c

N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: Application to Sansalvamide A peptide analogs

Ana I. Fernández-Llamazares
, Jesús García
, Vanessa Soto-Cerrato
, Ricardo Pérez-Tomás
, Jan Spengler
, Fernando Albericio

Institute for Research in Biomedicine
Biomaterials and Nanomedicine
University of Barcelona
University of KwaZulu-Natal

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.

Original language	English
Pages (from-to)	6430-6432
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	57
DOIs	https://doi.org/10.1039/c3cc41788c
State	Published - 20 Jun 2013
Externally published	Yes

Access to Document

10.1039/c3cc41788c

Cite this

@article{d91c0ad4f430452a87ca16844f0e287e,

title = "N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: Application to Sansalvamide A peptide analogs",

abstract = "Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.",

author = "Fern{\'a}ndez-Llamazares, \{Ana I.\} and Jes{\'u}s Garc{\'i}a and Vanessa Soto-Cerrato and Ricardo P{\'e}rez-Tom{\'a}s and Jan Spengler and Fernando Albericio",

year = "2013",

month = jun,

day = "20",

doi = "10.1039/c3cc41788c",

language = "Ingl{\'e}s",

volume = "49",

pages = "6430--6432",

journal = "Chemical Communications",

issn = "1359-7345",

number = "57",

}

TY - JOUR

T1 - N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group

T2 - Application to Sansalvamide A peptide analogs

AU - Fernández-Llamazares, Ana I.

AU - García, Jesús

AU - Soto-Cerrato, Vanessa

AU - Pérez-Tomás, Ricardo

AU - Spengler, Jan

AU - Albericio, Fernando

PY - 2013/6/20

Y1 - 2013/6/20

N2 - Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.

AB - Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.

UR - https://www.scopus.com/pages/publications/84880869061

U2 - 10.1039/c3cc41788c

DO - 10.1039/c3cc41788c

M3 - Artículo

C2 - 23752923

AN - SCOPUS:84880869061

SN - 1359-7345

VL - 49

SP - 6430

EP - 6432

JO - Chemical Communications

JF - Chemical Communications

IS - 57

ER -

N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: Application to Sansalvamide A peptide analogs

Abstract

Access to Document

Other files and links

Fingerprint

Cite this