L-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification

Gábor Radics; Beate Koksch; Salah M. El-Kousy; Jan Spengler; Klaus Burger

doi:10.1055/s-2003-41477

L-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification

Gábor Radics
, Beate Koksch
, Salah M. El-Kousy
, Jan Spengler
, Klaus Burger

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is described. The new compounds are GABA derivatives and represent new, versatile building blocks for peptide and depsipeptide modification.

Original language	English
Pages (from-to)	1826-1829
Number of pages	4
Journal	Synlett
Issue number	12
DOIs	https://doi.org/10.1055/s-2003-41477
State	Published - 2003
Externally published	Yes

Keywords

Amino acid hydroxamates
Arndt-Eistert synthesis
Citramalic acid
Curtius rearrangement
Hexafluoroacetone
Wolff rearrangement
γ-amino-α-hydroxy-α -methylbutyric acid

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10.1055/s-2003-41477

Cite this

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title = "L-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification",

abstract = "An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is described. The new compounds are GABA derivatives and represent new, versatile building blocks for peptide and depsipeptide modification.",

keywords = "Amino acid hydroxamates, Arndt-Eistert synthesis, Citramalic acid, Curtius rearrangement, Hexafluoroacetone, Wolff rearrangement, γ-amino-α-hydroxy-α -methylbutyric acid",

author = "G{\'a}bor Radics and Beate Koksch and El-Kousy, \{Salah M.\} and Jan Spengler and Klaus Burger",

year = "2003",

doi = "10.1055/s-2003-41477",

language = "Ingl{\'e}s",

pages = "1826--1829",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "12",

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TY - JOUR

T1 - L-α-Methylhomoisoserine

T2 - A New Versatile Building Block for Peptide and Depsipeptide Modification

AU - Radics, Gábor

AU - Koksch, Beate

AU - El-Kousy, Salah M.

AU - Spengler, Jan

AU - Burger, Klaus

PY - 2003

Y1 - 2003

N2 - An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is described. The new compounds are GABA derivatives and represent new, versatile building blocks for peptide and depsipeptide modification.

AB - An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is described. The new compounds are GABA derivatives and represent new, versatile building blocks for peptide and depsipeptide modification.

KW - Amino acid hydroxamates

KW - Arndt-Eistert synthesis

KW - Citramalic acid

KW - Curtius rearrangement

KW - Hexafluoroacetone

KW - Wolff rearrangement

KW - γ-amino-α-hydroxy-α -methylbutyric acid

UR - https://www.scopus.com/pages/publications/0142123041

U2 - 10.1055/s-2003-41477

DO - 10.1055/s-2003-41477

M3 - Artículo

AN - SCOPUS:0142123041

SN - 0936-5214

SP - 1826

EP - 1829

JO - Synlett

JF - Synlett

IS - 12

ER -

L-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification

Abstract

Keywords

Access to Document

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