Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste; Jonathan Liria; Naomi L. Forrester; Dileyvic Giambalvo; Maria Moncada; Kanya C. Long; Dulce Morón; Nuris de Manzione; Robert B. Tesh; Eric S. Halsey; Tadeusz J. Kochel; Rosa Hernandez; Juan Carlos Navarro; Scott C. Weaver

doi:10.3201/eid2110.141660

Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste
, Jonathan Liria
, Naomi L. Forrester
, Dileyvic Giambalvo
, Maria Moncada
, Kanya C. Long
, Dulce Morón
, Nuris de Manzione
, Robert B. Tesh
, Eric S. Halsey
, Tadeusz J. Kochel
, Rosa Hernandez
, Juan Carlos Navarro
, Scott C. Weaver

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

Original language	English
Pages (from-to)	1742-1750
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	21
Issue number	10
DOIs	https://doi.org/10.3201/eid2110.141660
State	Published - 1 Sep 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3201/eid2110.141660

Cite this

Auguste, A. J., Liria, J., Forrester, N. L., Giambalvo, D., Moncada, M., Long, K. C., Morón, D., de Manzione, N., Tesh, R. B., Halsey, E. S., Kochel, T. J., Hernandez, R., Navarro, J. C., & Weaver, S. C. (2015). Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010. Emerging Infectious Diseases, 21(10), 1742-1750. https://doi.org/10.3201/eid2110.141660

@article{7e6767e594dc42f3b6ac168b388236f1,

title = "Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010",

abstract = "In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estaci{\'o}n village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17\% nucleotide divergence across all 3 genotypes and 4\% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.",

author = "Auguste, \{Albert J.\} and Jonathan Liria and Forrester, \{Naomi L.\} and Dileyvic Giambalvo and Maria Moncada and Long, \{Kanya C.\} and Dulce Mor{\'o}n and \{de Manzione\}, Nuris and Tesh, \{Robert B.\} and Halsey, \{Eric S.\} and Kochel, \{Tadeusz J.\} and Rosa Hernandez and Navarro, \{Juan Carlos\} and Weaver, \{Scott C.\}",

year = "2015",

month = sep,

day = "1",

doi = "10.3201/eid2110.141660",

language = "Ingl{\'e}s",

volume = "21",

pages = "1742--1750",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "10",

}

Auguste, AJ, Liria, J, Forrester, NL, Giambalvo, D, Moncada, M, Long, KC, Morón, D, de Manzione, N, Tesh, RB, Halsey, ES, Kochel, TJ, Hernandez, R, Navarro, JC & Weaver, SC 2015, 'Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010', Emerging Infectious Diseases, vol. 21, no. 10, pp. 1742-1750. https://doi.org/10.3201/eid2110.141660

TY - JOUR

T1 - Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

AU - Auguste, Albert J.

AU - Liria, Jonathan

AU - Forrester, Naomi L.

AU - Giambalvo, Dileyvic

AU - Moncada, Maria

AU - Long, Kanya C.

AU - Morón, Dulce

AU - de Manzione, Nuris

AU - Tesh, Robert B.

AU - Halsey, Eric S.

AU - Kochel, Tadeusz J.

AU - Hernandez, Rosa

AU - Navarro, Juan Carlos

AU - Weaver, Scott C.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

AB - In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

UR - https://www.scopus.com/pages/publications/84942133568

U2 - 10.3201/eid2110.141660

DO - 10.3201/eid2110.141660

M3 - Artículo

C2 - 26401714

AN - SCOPUS:84942133568

SN - 1080-6040

VL - 21

SP - 1742

EP - 1750

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 10

ER -

Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this