An efficient synthesis of N-methylamino acids and some of their derivatives

Jan Spengler; Klaus Burger

doi:10.1055/s-1998-1998

An efficient synthesis of N-methylamino acids and some of their derivatives

Jan Spengler
, Klaus Burger

Leipzig University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Synthesis
Issue number	1
DOIs	https://doi.org/10.1055/s-1998-1998
State	Published - Jan 1998
Externally published	Yes

Keywords

Hexafluoroacetone
N-chloromethylation
N-methylamino acids and derivatives
Triethylsilane

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10.1055/s-1998-1998

Cite this

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title = "An efficient synthesis of N-methylamino acids and some of their derivatives",

abstract = "N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.",

keywords = "Hexafluoroacetone, N-chloromethylation, N-methylamino acids and derivatives, Triethylsilane",

author = "Jan Spengler and Klaus Burger",

year = "1998",

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doi = "10.1055/s-1998-1998",

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pages = "67--70",

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AU - Burger, Klaus

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AB - N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

KW - Hexafluoroacetone

KW - N-chloromethylation

KW - N-methylamino acids and derivatives

KW - Triethylsilane

UR - https://www.scopus.com/pages/publications/0031983889

U2 - 10.1055/s-1998-1998

DO - 10.1055/s-1998-1998

M3 - Artículo

AN - SCOPUS:0031983889

SN - 0039-7881

SP - 67

EP - 70

JO - Synthesis

JF - Synthesis

IS - 1

ER -

An efficient synthesis of N-methylamino acids and some of their derivatives

Abstract

Keywords

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