Abstract
N-Methylaspartic acid derivatives and its homologues are obtained by a stereoconservative one-pot procedure from hexafluoroacetone-protected aspartic and glutamic acid, 2a and 2b, respectively, α-Aminoadipic acid (5c) and its derivative 6c are accessible from the corresponding glutamic acid derivative 9b by a Wolff rearrangement. A variety of homochiral N-methylamino acids, 5 and 12, and their derivatives, 6 and 8-11, become readily available by the new synthetic concept.
| Original language | English |
|---|---|
| Pages (from-to) | 199-204 |
| Number of pages | 6 |
| Journal | European Journal of Organic Chemistry |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2000 |
| Externally published | Yes |
Keywords
- Hexafluoroacetone
- N-Methyl- α-aminoadipic acid
- N-Methylaspartic acid
- N-Methylglutamic acid
- N-Methylthiazol-4-yl-α-amino acids
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